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The incidence of non-healing cutaneous wounds is 5 to 7 million per year in the United States. It is estimated that this clinical volume results in over a 20 billion dollar cost to the healthcare system. Wound healing is a complex process that involves a coordinated integration of numerous clinical and biochemical pathways. The replacement of injured or damaged tissue can be compromised by multiple factors including but not limited to: obesity, diabetes, smoking, vascular disease, infection, renal failure, cancer, and malnutrition. 

A classic example of a non-healing wound is a diabetic foot ulceration. With decreased sensation and frequently concomitant peripheral vascular disease, chronic ulcers can easily form in this ever-growing population. With an estimated 366 million diabetic patients by 2030, we can expect an increasing number of patients with chronic non-healing wounds in the future. With an aging society, it is also expected that there will be an increase in the number of surgical wounds, venous leg ulcerations, and traumatic wounds that will be at risk for non-healing. Further complicating the situation is the lack of formal education for physicians, nurses, therapists, and all ancillary health care providers on the science and treatment of non-healing wounds.